TRAJENTA DUO 2.5/500MG TABLET

Ingredent :- Linagliptin (2.5 mg) + Metformin Hydrochloride (500 mg)

Use for :- TRAJENTA DUO 2.5/500MG TABLET – Used for controlling blood sugar in type 2 diabetes.

Units of :- Packing of 10 Tablets Strip

1. Indications
   – Type 2 Diabetes Mellitus: Used to lower blood glucose levels in adults with type 2 diabetes.
   – Failed Monotherapy: Indicated when Metformin alone doesn’t adequately control blood sugar.
   – Preventing Complications: Aims to prevent diabetes-related complications like neuropathy, nephropathy, and retinopathy.

2. Benefits
   – Glucose-Dependent Action: Linagliptin increases insulin and reduces glucagon in a glucose-dependent manner.
   – Weight Neutral: Unlike other anti-diabetic agents, it typically does not lead to weight gain.
   – Cardiovascular Safety: Clinically tested for cardiovascular neutrality, making it suitable for patients with heart concerns.
   – Low Hypoglycemia Risk: Especially beneficial for older adults or those at risk of low blood sugar episodes.

3. Dosage and Administration
   – Dosage: Commonly prescribed as one tablet twice daily, with meals.
   – Administration: Take with food to reduce gastrointestinal side effects from Metformin.
   – Missed Dose: Skip the missed dose if close to the next one. Do not double the dose.

4. Mechanism of Action
   – Linagliptin: Inhibits DPP-4 enzyme, increasing GLP-1 and GIP levels, enhancing insulin secretion.
   – Metformin: Reduces hepatic glucose production and improves peripheral glucose uptake.

5. Side Effects
   – Common Side Effects: Diarrhea, nausea, stomach discomfort, and mild headache.
   – Rare Side Effects: Pancreatitis, lactic acidosis, and allergic skin reactions.
   – Long-Term Use: Regular monitoring may be necessary for kidney function and vitamin B12 levels.

6. Precautions
   – Kidney Health: Not recommended in patients with significantly reduced kidney function.
   – Alcohol Intake: Should be limited to avoid lactic acidosis risk.
   – Surgery or Scans: Inform doctor before surgery or X-ray tests involving contrast dye.
   – Pregnancy: Use only if clearly needed and prescribed by a doctor.

7. Conclusion
TRAJENTA DUO 2.5/500MG TABLET is a dependable treatment option for managing type 2 diabetes, especially in patients seeking a weight-neutral and low-hypoglycemia solution. Its combination of Linagliptin and Metformin makes it effective, safe, and suitable for long-term glycemic control when paired with healthy habits.