ALBUREL INJECTION 20% 100ML

Ingredent :- Human Albumin

Use for :- ALBUREL INJECTION 20% 100ML – Used for treating low blood volume and protein levels.

Units of :- Packing of 100 ml vial

1. Indications
    – Hypovolemia: Recommended for restoration of blood volume due to surgical blood loss, trauma, or dialysis .

    – Hypoalbuminemia: Used when low protein levels in the blood require correction, e.g., liver disease or nephrosis .

    – Burns and Critical Illness: Employed to manage fluid redistribution and protein loss in severe burns .

    – Paracentesis in Cirrhosis: Administered post-large-volume ascitic fluid removal to prevent circulatory collapse .

 
2. Benefits
    – Rapid Volume Expansion: Quickly restores circulatory fluid volume and raises oncotic pressure.
    – Hemodynamic Stability: Maintains blood pressure and perfusion, reducing risk of organ dysfunction.
    – Protein Restitution: Replaces critical albumin lost in severe illness or surgery.
    – Localized Action: Works intravenously with minimal systemic interference and no metabolic conversion.

 
3. Dosage and Administration
    – Adults: Typically 25 g dose (≈100 mL) infused slowly; can be titrated to patient needs based on blood pressure and perfusion 
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    – Children/Newborns: Dosing based on weight; e.g., 1 g/kg for neonates .
    – Severe Ascites: 8 g albumin per 1 L fluid removed during paracentesis .
    – Administration: IV use only; inspect for turbidity, infuse at controlled rates while monitoring vitals 
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4. Mechanism of Action
    – Oncotic Effect: Increases plasma oncotic pressure, drawing water into circulatory system.
    – Fluid Distribution: Helps maintain blood volume and reduce edema.
    – Protein Supply: Restores plasma protein levels for colloidal balance and drug-binding capacity.
    – Systemic Stability: Minimal metabolism—systemic effect is limited to blood compartment.

 
5. Side Effects
    – Hypersensitivity: Possible allergic reactions, including rash, fever, or anaphylaxis 
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    – Fluid Overload: Risk of pulmonary edema or hypertension in susceptible patients 
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    – Electrolyte Disturbances: Potential sodium or potassium imbalances .
    – Mild Symptoms: Transient nausea, chills, fever, flushing .

 
6. Precautions
    – Renal/Cardiac Patients: Use cautiously to avoid circulatory overload.
    – Hypersensitivity History: Monitor carefully for infusion reactions.
    – Hematological Surgery: Adjust doses to avoid anemia from hemodilution.
    – Monitoring: Close monitoring of vitals, blood pressure, and electrolytes.

 
7. Conclusion
ALBUREL INJECTION 20% 100ML is an essential plasma expander used in critical care to manage hypovolemia, hypoalbuminemia, and fluid shifts. It restores circulatory volume, supports protein correction, and ensures hemodynamic stability. Proper dosing, monitoring, and cautious use are paramount to maximize benefits and minimize risks.