KM CZS TABLET

Ingredients :- Ketoconazole (200 mg) + Miconazole (50 mg)

KM CZS TABLET – Used for treating fungal infections.

Packing of 10 tablets strip

1. Indications
    – Respiratory Tract Infections: Indicated for treatment of infections such as bronchitis, pneumonia, and sinusitis caused by susceptible bacteria.

    – Urinary Tract Infections: Effective in treating uncomplicated and complicated urinary tract infections.

    – Skin and Soft Tissue Infections: Used in infections like cellulitis, abscesses, and wound infections.

    – Other Infections: May be prescribed for infections involving bones, joints, and intra-abdominal infections as determined by the physician.

 
2. Benefits
KM CZS TABLET provides several clinical advantages:

    – Broad Spectrum Activity: Effective against a wide range of gram-positive and gram-negative bacteria.

    – Combination Therapy: Helps overcome bacterial resistance by combining two agents with synergistic effects.

    – Convenient Oral Form: Easy to administer and ensures good patient compliance.

    – Rapid Symptom Relief: Helps in reducing infection symptoms such as fever, pain, and inflammation.

 
3. Dosage and Administration
Proper use is important for best therapeutic outcomes:

    – Recommended Dosage: As prescribed by the healthcare provider, depending on the type and severity of infection, typically one or two tablets taken orally every 12 hours.

    – Administration: Should be taken with a full glass of water, preferably after meals to reduce gastrointestinal discomfort.

    – Duration: Complete the full course of therapy even if symptoms improve early, to prevent resistance.

    – Missed Dose: Take as soon as remembered unless it is near the time for the next dose. Do not double dose.

 
4. Mechanism of Action
KM CZS TABLET works by:

    – Inhibiting Bacterial Cell Wall Synthesis: One component interferes with the formation of bacterial cell walls, leading to cell death.

    – Beta-lactamase Inhibition: The other component inhibits beta-lactamase enzymes produced by resistant bacteria, thereby enhancing the antibiotic effect.

    – Synergistic Effect: The combination enhances bacterial eradication and reduces the risk of resistance development.

 
5. Side Effects
Side effects may include:

    – Gastrointestinal Upset: Nausea, vomiting, diarrhea, and abdominal pain are common but usually mild.

    – Allergic Reactions: Rash, itching, and in rare cases, severe hypersensitivity including anaphylaxis.

    – Clostridium difficile Infection: Prolonged use may lead to superinfection with resistant bacteria or fungi.

    – Other: Headache, dizziness, and mild elevation of liver enzymes.

 
6. Precautions
Consider the following before use:

    – Allergy History: Inform the doctor of any allergies to penicillins, cephalosporins, or other antibiotics.

    – Kidney and Liver Function: Dosage adjustments may be necessary in patients with renal or hepatic impairment.

    – Drug Interactions: Inform healthcare providers about all medications being taken to avoid interactions.

    – Pregnancy and Lactation: Use only if clearly needed and under medical supervision.

 
7. Conclusion
In conclusion, KM CZS TABLET is an effective antibiotic combination useful in treating various bacterial infections. It offers broad-spectrum activity and helps combat resistant bacteria through its synergistic action. Following prescribed dosage and completing the full course is essential to maximize benefits and minimize side effects and resistance.