PENATE 40MG TABLET

Ingredients :- Perindopril

PENATE 40MG TABLET – Used for managing hypertension and heart failure.

Packing of 10 tablets strip

1. Indications
    – Gastroesophageal reflux disease (GERD) and heartburn relief.

    – Duodenal and gastric ulcers—treatment and prevention.
    – Erosive esophagitis and acid-related dyspepsia.
    – Zollinger–Ellison syndrome (gastrin-producing tumors).

    – NSAID-related ulcer prevention.

 
2. Benefits
    – Acid suppression promotes healing of ulcers and reflux damage.
    – Offers long-lasting relief from heartburn and dyspepsia.
    – Improves quality of life in GERD patients.
    – Preventive protection in patients on NSAIDs or with ulcer history.
    – Reduces esophagitis and lower esophageal inflammation.

 
Dosage and Administration

    – Adults: 40 mg orally once daily, typically one hour before breakfast.

    – Standard treatment: 4–8 weeks for ulcers or GERD; long-term therapy for chronic conditions.
    – Swallow whole—not to be chewed or crushed.
    – If a dose is missed, take as soon as remembered unless it’s near the next dose—do not double.

 
Mechanism of Action

    – Blocks the proton pump enzyme (H⁺/K⁺ ATPase) in stomach cells.

    – Suppresses gastric acid secretion, raising pH to ease mucosal repair.
    – Duration of action lasts ~24 hours per dose, enabling once-daily use.

 
Side Effects

    – Common: headache, diarrhea, nausea, abdominal discomfort, flatulence, dizziness.

    – Prolonged use may increase risk of bone fractures, magnesium or B12 deficiency.

    – Rare: rash, abnormal liver/kidney function—seek medical advice.

 
6. Precautions
    – Long-term use (over 1 year) should involve B12 and bone density monitoring.

    – Not suitable for children under 5; dose adjustment for elderly and liver/kidney impairment.
    – Possible interactions with drugs like warfarin, certain antibiotics, methotrexate.
    – Avoid alcohol and trigger foods; adopt lifestyle modifications (smaller meals, no late dinners).

 
7. Conclusion
PENATE 40MG TABLET is a trusted PPI for treating and preventing acid-related gastrointestinal disorders. Its strong, long-lasting acid suppression supports healing and symptom control. Safe for long-term treatment when appropriately monitored and combined with healthy lifestyle habits.