PHOSCUT 400 TABLET

Ingredent :- Sevelamer

Use for :- PHOSCUT 400MG TABLET – Used to control high phosphate levels in the blood, particularly in patients with chronic kidney disease on dialysis.

Units of :- Packing of 10 tablets strip

1. Indications
   – Hyperphosphatemia: Used to treat elevated serum phosphate in patients with end-stage renal disease on dialysis to prevent complications such as itching, bone pain, and vascular calcifications.

   – Dialysis Maintenance: Prescribed to dialysis patients who cannot regulate phosphate through diet alone.

 
2. Benefits
PHOSCUT 400 TABLET offers crucial therapeutic benefits in renal care:

   – Reduces Intestinal Phosphate Absorption: Binds phosphate from food, minimizing blood phosphate spikes after meals.

   – Prevents Renal Bone Disease: Helps manage mineral-bone disorders common in dialysis patients.
   – Decreases Pruritus & Soft-Tissue Calcification: Helps alleviate itching and tissue calcification risk.

   – Non-Systemic Action: Acts within the gut without systemic absorption, minimizing systemic side effects.

 
3. Dosage and Administration
For optimal effectiveness and safety, follow these instructions:

   – With Meals: Always take with food to bind the phosphate present in meals.

   – Follow Prescribed Dose: Dosage individualized by a nephrologist based on phosphate levels.
   – Swallow Whole: Do not chew or crush tablets—this helps to reduce gastrointestinal side effects.

   – Missed Dose: Skip missed dose and continue routine schedule; do not double dose.

 
4. Mechanism of Action
PHOSCUT 400 TABLET works through a phosphate-binding mechanism:

   – Chelates Dietary Phosphate: Binds phosphate in the gut, preventing systemic absorption.

   – Promotes Phosphate Excretion: Bound phosphate is expelled in stool.
   – Local GI Effect: Acts within the gut, minimizing systemic exposure.

 
5. Side Effects
Common side effects are generally tolerable and often mild:

   – Gastrointestinal Issues: Includes nausea, vomiting, abdominal pain, diarrhea, constipation, flatulence, dyspepsia.

   – Potential Reduced Absorption of Nutrients: May impair calcium and fat-soluble vitamin absorption; supplementation may be needed.
   – Rare Serious Reactions: Bowel obstruction/perforation reported in rare cases—seek immediate care.

 
6. Precautions
Certain considerations ensure safe and effective use:

   – Avoid in Hypophosphatemia: Contraindicated in patients with abnormally low phosphate.
   – Bowel Obstruction: Avoid if present or suspected.
   – Medication Interactions: May reduce absorption of other oral drugs—take them hours apart.
   – Pregnancy & Breastfeeding: Use only if clearly needed, after consulting your physician.

   – Monitor Blood Minerals: Watch for changes in serum calcium, vitamin levels during treatment.

 
7. Conclusion
PHOSCUT 400 TABLET is a vital therapy for managing hyperphosphatemia in dialysis-dependent kidney failure patients. Its gut-acting phosphate-binding effect helps protect against complications like bone disease, calcification, and itching. While generally safe, close attention to gastrointestinal tolerance, nutrient levels, and bowel health is essential. Adhering to prescribed dosage, dietary guidelines, and medical oversight ensures the best outcomes for long-term renal health.