RITRIVE LS TABLET

Ingredent :- Risperidone + Trihexyphenidyl

Use for :- RITRIVE LS TABLET – Used for the treatment of mental disorders like schizophrenia and bipolar disorder.

Units of :- Packing of 10 tablets strip

1. Indications
    – Schizophrenia & Psychosis: Alleviates hallucinations, delusions, disorganized thoughts .
 
    – Bipolar Mania: Controls acute manic episodes and stabilizes mood .
 
    – Autism-Related Irritability: Reduces aggressive and self-injurious behaviors in children/adolescents .
 
    – Extrapyramidal Symptoms: Prevents and treats antipsychotic-induced movement disorders via its anticholinergic component .

 
2. Benefits
    – Antipsychotic Effects: Balances dopamine and serotonin to improve thought clarity, mood, social interaction.
 
    – Mood Stabilization: Effective in acute mania and long-term bipolar maintenance .
 
    – Movement Disorder Control: Counteracts EPS like tremors, rigidity, and dystonia caused by antipsychotics .
 
    – Quality of Life: Restores social and occupational function by improving behavior and reducing side effects.

 
3. Dosage and Administration
    – Typical Adult Dose: Depends on condition, generally 2–3 mg daily of the antipsychotic component, with anticholinergic dose adjusted accordingly .
 
    – Titration: Tailored by physician based on symptom severity and tolerability.
 
    – Administration: Take orally, with or without food, at the same time daily, usually in the evening .
 
    – Pediatric Guidance: For irritability in autism, doses may begin at 0.25–0.5 mg risperidone twice daily with adjunctive trihexyphenidyl.
 
    – Missed Dose: Take as soon as remembered, or skip if close to next. Do not double dose.

 
4. Mechanism of Action
    – Dopamine/Serotonin Blockade: Risperidone antagonizes D₂ and 5-HT₂ receptors to correct chemical imbalances in the brain.
 
    – Anticholinergic Support: Trihexyphenidyl reduces drug-induced EPS by blocking excessive cholinergic activity.
 
    – Balanced Therapy: Offers antipsychotic effectiveness with fewer movement-related side effects.

 
5. Side Effects
    – Common: Includes drowsiness, dizziness, dry mouth, constipation, N/V, blurred vision, weight gain, orthostatic hypotension, tremors, raised prolactin levels.
 
    – Metabolic Issues: Risk of increased blood sugar, cholesterol, and triglycerides, particularly with long-term use.
 
    – Neurological Reactions: May cause akathisia, dystonia, urinary retention—especially in elderly or children .
 
    – Rare: Allergic reactions, movement disorders, changes in vision, increased infection susceptibility.

 
6. Precautions
    – Cognitive/Motor Impairment: Avoid driving until reaction known.
 
    – Cardiovascular/Renal/Hepatic Monitoring: Use cautiously, adjust dose in vulnerable populations.
 
    – Pregnancy/Breastfeeding: Consult a doctor; contraindicated unless benefit outweighs risk.
 
    – Drug Interactions: Avoid alcohol; may interact with antihypertensives, CNS depressants.
 
    – Discontinuation: Do not stop abruptly to prevent rebound symptoms; taper under medical supervision.

 
7. Conclusion
In conclusion, RITRIVE LS TABLET offers targeted treatment for psychosis, bipolar mania, autism‑related irritability, and medication-induced movement disorders—combining efficacy and EPS management. Consistent use at prescribed doses, close monitoring of metabolic, neurological, and cardiac health, and adherence to administration guidelines ensure optimal therapeutic outcomes while minimizing risks.